Intestinal permeability of atractylenolides across the human Caco-2 cell monolayer model
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چکیده
منابع مشابه
Intestinal permeability of sesquiterpenes in the caco-2 cell monolayer model.
The intestinal permeability of eight sesquiterpenes which are active constituents of some traditional Chinese medicines, were studied by using the Caco-2 cell monolayer; they include tanacetin, artesin, magnolialide, crossostephin, atractylon, isocalamenediol (ICL), bisabolangelone (BSE) and (3 R)-des- O-methyllasiodiplodin (DML). The bidirectional permeability of the eight sesquiterpenes was s...
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The absorption of orally administered drugs requires their movement across the intestinal epithelial barrier. Poor intestinal permeability leads to limited absorption. Generally, if a compound achieves a 90% or greater oral absorption, it is considered highly permeable (for example, propranolol or metoprolol). Drugs that display 50% or less oral absorption are considered poorly permeable (for e...
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The uptake and transport of 9-nitrocamptothecin (9-NC), a potent anticancer agent, across Caco-2 cell monolayers was studied as a free and PLGA nanoparticle loaded drug. Different sizes (110 to 950 nm) of 9-nitrocamptothecin nanoparticles using poly (lactic-glycolic acid) were prepared by via the nanoprecipitation method. The transport of nanoparticles across the Caco-2 cell monolayer as a func...
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The uptake and transport of 9-nitrocamptothecin (9-NC), a potent anticancer agent, across Caco-2 cell monolayers was studied as a free and PLGA nanoparticle loaded drug. Different sizes (110 to 950 nm) of 9-nitrocamptothecin nanoparticles using poly (lactic-glycolic acid) were prepared by via the nanoprecipitation method. The transport of nanoparticles across the Caco-2 cell monolayer as a func...
متن کاملStudy of the Biotransformation of Tongmai Formula by Human Intestinal Flora and Its Intestinal Permeability across the Caco-2 Cell Monolayer.
Tongmai formula (TMF) is a well-known Chinese medicinal preparation that contains isoflavones as its major bioactive constituents. As traditional Chinese medicines (TCMs) are usually used by oral administration, their fate inside the intestinal lumen, including their biotransformation by human intestinal flora (HIF) and intestinal absorption deserves study. In this work TMF extract was incubate...
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ژورنال
عنوان ژورنال: Journal of Chinese Pharmaceutical Sciences
سال: 2011
ISSN: 1003-1057
DOI: 10.5246/jcps.2011.05.064